“Does intelligence REALLY come from our mothers?”

You’ve probably seen the headlines:

New research confirms that kids get their intelligence from mom -GH Sep 12, 2016

Science says you can thank (or blame) your mum for your intelligence-Yahoo Sep 14, 2016

Children inherit their intelligence from their mother not their father, science says-UK Independent. Oct 7, 2016

But what is this “new research” and what does science really say about the source of our smarts?

It turns out the mother of all these headlines isn’t actually new research at all. These articles refer to a blog post that references studies ranging from 1972 to 2012. We reviewed these studies, contacted the scientists, and dug into the literature on IQ inheritance to figure out what the science really says.

First, intelligence is tough to define. IQ tests clearly don’t reveal a natural ability, because scores improve with practice. And genes linked to high IQ’s only account for about 1-2% of intelligence. With so little data on smart genes, how could anyone claim intelligence is inherited from our mothers?

The whole crux of the argument is that “most of a child’s intelligence depends on the X chromosome.”

In one study cited, more genes known to be associated with mental disabilities were found on the X chromosome than on non-sex chromosomes. But the authors note:

“cognitive ability is a complex trait… a healthy lifestyle of the mother during pregnancy, well-balanced nutrition, and intensive and responsible care by the parents are far more important factors”

Another study identified 7 genes linked to mental disorders on the X-chromosome, but X-chromosome mutations are inherently easier to study. Women have two X-chromosomes while men have an X and a Y, so we only actually need one functional X-chromosome. That’s why men are more likely to develop certain disorders such as Autism or color-blindness which are associated with mutations on the X-chromosome. The X chromosome is clearly important for brain development, but there are also mental disorders linked to other chromosomes. For example, Down Syndrome is caused by an extra copy of chromosome 21. The authors speculate:

“to keep a complex organ such as the human brain functioning normally requires not one, not two, but hundreds or thousands of genes”

Even if there are a host of genes important for brain function on the X-chromosome, females also inherit an X chromosome from their dad. Here’s how the blog accounts for this: “One of the first studies in this area was conducted in 1984…there are conditioned genes which are activated only when inherited from the mother…maybe they could even result in some brain functions”

The problem is, brain tissue isn’t actually mentioned in any of the studies referenced from 1984. These studies monitored the development of mouse embryos created by fusing either two female or two male genomes. There were differences which could be explained by imprinting: when one copy of a gene (either the maternal or the paternal) is turned off. These are the “conditioned genes” mentioned in the blog, but they were not linked to brain development in these studies.

Two additional studies (from 1995 and 1996) also created mouse embryos in which some cells contained only maternal or only paternal genes. In these, brain tissue was discussed, and the blog concludes: “cells that had paternal genes accumulate in some of the emotional centers of the brain…researchers have not found any paternal cells in the cerebral cortex, which is where are developed the most advanced cognitive functions”

Cells in the cerebral cortex were more likely to contain strictly maternal genes, but this was not universally true. A similar correlation was also found in primates (in 1996). We asked Dr. James Curley if this difference related to intelligence:

“I wouldn’t conflate expression of genes in the cortex being a proxy for intelligence.  The expression of these genes obviously contribute to the development of brain regions and neural circuits involved in the control of behaviors related to intelligence such as learning and memory – but each gene would need to be studied for its role to gain further understanding.”

On the other hand, another study (not cited in the blog post) showed that females with turner syndrome have a thicker cortex if their X chromosome is inherited from their father. Clearly, brain development is complicated.

The remaining studies cited by the blog all considered the effect nurturing has on intelligence, but did not measure differences between maternal and paternal care. The first study found that attachment with mom influenced how toddlers problem solve. This was described as enthusiasm, persistence, and cooperation. This could be described as intelligence, depending on your definition.

From a study investigating the link between breastfeeding and a child’s intelligence, the blog concluded that “the best predictor of intelligence was the IQ of the mother”

But this study mainly showed that intelligent mothers were more likely to breastfeed, and that breastfeeding had little to no effect on the child’s intelligence. The father’s IQ wasn’t even considered.

Of the most recent study cited (2012), the blog claims, “when the mothers were emotionally supportive…the hippocampus of the kids at age 13 was 10% greater.” But, the author of this study, Dr. Joan Luby, said this was not an accurate explanation:

“Our interpretation here was that this was a psychosocial phenomenon—not a genetic one and was caregiver specific not gender specific.”

The one study that did discuss a genetic component found that mutations in a certain paternally expressed gene in mice lead to poor nurturing habits in mothers, but intelligence wasn’t considered at all.

While it makes for a good headline, inheritance of complex traits can’t be boiled down to a simple statement like “intelligence is inherited from mothers”

 

About the Authors

Jenna E Gallegos, Katharine Nichole Holm, and Christian Silva are PhD students at the University of California in Davis. This post was written as part of a project called “Science REALLY says” which seeks to ensure scientific data is accurately represented by the media. For more content from the UC Davis science communcation group “Science Says“, follow us on twitter @SciSays

Acknowledgements

We thank Dr. Barry Keverne (Professor of Neuroscience, University of Cambridge), Dr. James Curley (Professor of Neuroscience and Development Columbia University),  and Dr. Joan Luby (Professor of Child Psychiatry, Washington University) for helpful comments.

References

Matas L, et al. (1978) Continuity of adaptation in the second year The relationship between quality of attachment and later competence. Child Development 49:547-556

Barton SC, et al. (1984) Role of paternal and maternal genomes in mouse development. Nature 311:374-376

McGrath J & Solter D. (1984) Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell 37(1):179-183

Surani MA, et al. (1984) Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis. Nature 308(5959):548-550

Allen ND, et al. (1995) Distribution of parthenogenetic cells in the mouse brain and their influence on brain development and behavior. PNAS 92(23)10782-10786

Keverne EB, et al. (1996) Genomic imprinting and the differential roles of parental genomes in brain development. Dev Brain Res 92(1):91-100

Keverne EB, et al. (1996) Primate brain evolution: genetic and functional considerations. Proc Biol Sci 263(1371):689-696

Gecz J & Mulley J (2001) Genes for Cognitive Function: Developments on the X. Genome Res 10(2):157-63

Zechner U, et al. (2001) A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution? Trends Genet 17(12):697-701

Curley J, et al. (2004) Coadaptation in mother and infant regulated by a paternally expressed imprinted gene. Proc Biol Sci 271(1545):1303-1309

Der G, et al. (2006) Effect of breastfeeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis. BMJ 333(7575):945

Chabris CF, et al. (2011) Most Reported Genetic Associations With General Intelligence Are Probably False Positives. Psych Sci 23(11):1314-1323

Davies G (2011) Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular Psychiatry 16(10):996-1005

Luby JL, et al. (2012) Maternal support in early childhood predicts larger hippocampal volumes at school age. PNAS 109(8):2854-2859

Hayden EC (2013) Ethics: Taboo genetics. Nature 502(7469):26-28

Lepage J-F (2013) Genomic Imprinting Effects of the X Chromosome on Brain Morphology. J of Neurosci 33(19):8567-8574

Rietveld CA (2013) GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science 340(6139):1467-1471

 

 

 

2 thoughts on ““Does intelligence REALLY come from our mothers?”

  1. Pingback: Yet Another Reason to Say Thank You MOM. Study Suggest Mother’s Gene Responsible for Intelligence of their Children. - #SoHeDID

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